PhD student Kieran Nolan created "meta game" CONTROL as part of the Game Pack 01 compilation from LA Game Space. Apparently playing CONTROL is pretty finger cramp-y as you press flashing buttons and try not to make a wrong move that will send the game into "meta glitch mode with excruciating digital sounds."
Kieran's research is about exploring the "collision of videogame aesthetics, new media art, and interaction design." The culmination of that research via CONTROL comments on the use of teeny plastic controllers and Atari joysticks to control on-screen motion. Or something. In any event, the idea and execution is rad-i-cool.
After you check out the trailer below, find more self-aware games at LA Game Space.